Progress - Innovation - Macromolecular Journals

Progress in rational methods of cryoprotection in macromolecular crystallography

Cryogenic cooling of macromolecular crystals is commonly used for X-ray data collection both to reduce crystal damage from radiation and to gather functional information by cryogenically trapping intermediates. However, the cooling process can damage the crystals. Limiting cooling-induced crystal damage often requires cryoprotection strategies, which can involve substantial screening of solutio...

Macromolecular structure databases: past progress and future challenges.

Databases containing macromolecular structure data provide a crystallographer with important tools for use in solving, refining and understanding the functional significance of their protein structures. Given this importance, this paper briefly summarizes past progress by outlining the features of the significant number of relevant databases developed to date. One recent database, PDB+, contain...

Health care innovation: a progress report.

Clinical trials: innovation, progress and controversy.

Technology Adoption under Uncertain Innovation Progress

Within uncertain technological progress, a firm has to decide when to update its technology and select a new one among a non-decreasing range over time. Under constant return to scale, the best existing technology is implemented. Replacement is triggered not only when the firm operated technology is sufficiently obsolete but also the wedge between the latest and the state of the arts grades is ...